Stress, Anxiety and Type A Personality and Analgesics

Aarhus University Hospital60 enrolled

Overview

Patients scheduled for elective cardiac surgery are preoperative evaluated using different personality type, stress and anxiety tests. Patient are randomized to receive the investigators' standard moderate dose sufentanil (bolus 1microgram/kg and propofol 0.03 mg/kg/min) or low dose sufentanil (bolus 0.5 microgram/kg and propofol 0.06 mg/kg/min).

Patients randomized and the type of induction informed to the anaesthetist 30 minutes before surgery. Patients are monitored before induction of anesthesia. Propofol is started on the randomized infusion rate. Sufentanil bolus are given according to randomization. BIS level is followed. Time to reach BIS \< 50 is monitored. BIS after 30, 60 and 90 minutes are registered. Lowest BIS during surgery are registered. Total amounts of sufentanil and propofol recorded.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

Conditions

Postoperative; Dysfunction Following Cardiac Surgery

Interventions

Sufentanil IDRUG

bolus dose of sufentanil 1 microgram/kg

Sufentanil IIDRUG

bolus dose of sufentanil 0.5 microgram/kg

Propofol IDRUG

Continued dose of propofol 0.03 mg/kg/min

Propofol II

Eligibility

Min age: 16 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All elective cardiac surgery patients Exclusion Criteria: * Patients requiring special attention or monitoring during induction * Patients with expected longer postoperative ventilation time * Patients allergic to sufentanil and or propofol * Participation in other projects * Pregnancy

Outcomes

Primary Outcomes

Association between preoperative personality/stress/anxiety and time (minutes) to reach anaesthetic depth goal by bi-spectral index (BIS)

Minutes to reach BIS 50

Time frame: Up to 30 minutes

Potential of sufentanil regime on fast-track measured by ventilation time and association with eligible discharge from intensive care unit.

Postoperative ventilation time (hours/minutes) and the association to eligible discharge from ICU.

Time frame: Up to 24 hours

Secondary Outcomes

Sufentanil regime and association to haemodynamic parameters (blood pressures, heart rate, cardiac output, oxygenation)

Perioperative changes in haemodynamic parameters (analysis of varians) of haemodynamic parameters according to sufentanil regime

Time frame: up to 24 hours

Association between preoperative personality/stress/anxiety tests and postoperative care using postoperative quality score

Association of preoperative tests and the postoperative ICU quality scoring

Time frame: up to 24 hours

Association between preoperative personality/stress/anxiety and total amounts of sufentanil and propofol

Amounts of drugs as pr kg pr time unit of involved drugs

Time frame: Up to 12 hours

Data from ClinicalTrials.gov

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