Neutrophil-to-Lymphocyte Ratio in Bladder Cancer: A Secondary Biomarker Analysis of SWOG 8710

Inclusion Criteria: 1. SWOG 8710 original trial inclusion criteria included: * Node-negative, muscle-invasive transitional cell carcinoma of the bladder, T2-T4aN0M0 per the AJCC 4th edition staging manual. * SWOG performance status of 0 or 1 * Adequate organ function by lab criteria (WBC \> 4,000 cells/mm3, platelets \>150,000 cells/mm3, creatinine \<1.5 md/dL (men) or \<1.3 md/dL (women), baseline liver tests \< 2 times normal limits) 2. Inclusion criteria for this secondary analysis are: * Eligible for original SWOG 8710 trial * Had complete blood count with differential prior to first treatment (radical cystectomy or NAC). Exclusion Criteria: 1. SWOG 8710 original trial exclusion criteria included: * No age restrictions * Previous or concomitant malignancy other than bladder cancer or basal cell skin cancer * Prior pelvic radiation * Metastatic or incurable disease * Laboratory values exceeding those detailed in 3.1.c 2. Exclusion criteria for this secondary analysis are: * Ineligibility for the original SWOG 8710 study * Lack of complete blood count with differential prior to first treatment (cystectomy or NAC).