Ischeic reperfusion injury lead to a cellular dyfunction and increase in soluble glycocalyx of blood flow. syndecan-1 was a marker of glycocalyx. The purpose of this study is to prove the variation of level of serum syndecan-1 between preoperative and postoperative period.
The patients were allocated randomly to receive propofol or desflurane. Also, a total of 6ml of blood sample was obtained for total 6 times in consecutive order. 1. Preoperation (immediate before anesthesia induction) 2. Immediate before tourniquet off 3. 5 min after tourniquet off 4. PACU 5. postoperative 6 hours 6. postoperative 24 hours Serum in blood will be obtained and level of serum cytokine will be evaluated by enzyme-linked immunosorbent assay
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
80
Patient will be anesthetized by using propofol infusion during operation.
Patient will be anesthetized by using desflurane inhalation during operation.
Konkuk University Medical Center
Seoul, South Korea
Syndecan-1
change of level of syndecan-1 (scores range from 0 to 100)
Time frame: Preoperative time, Immediate before tourniquet off,5 min after tourniquet off,PACU, postoperation after 6hours, postoperation after 24hours
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