The standard recommended management of spontaneous bacterial peritonitis (SBP) includes a third-generation cephalosporin (cefotaxime or ceftriaxone) and high dose albumin (1.5g/kg on day 1 and 1g/kg on day 3). The major drawback of the current recommendations is the high price of albumin. In the current randomized control trial investigators compared the effect of standard recommended dose of albumin (1.5g/kg on day 1 and 1g/kg on day 3) vs. low dose (20g/d for 5 days) on the resolution of SBP and subsequent cytokine changes in ascitic fluid and blood.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
40
Albumin in two different doses
Change in neutrophils/mm in ascitic fluid
Time frame: 3 days
Change in IL-6, IL-1, TNF in ascitic fluid and serum between the two groups
Time frame: 5 days
Survival in days at the end of therapy
Time frame: 5 days
Differences in frequency of sepsis, renal failure and other organ failures between the two groups
Time frame: 5 days
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