The purpose of this study is to estimate antihypertensive effect of azilsartan medoxomil (Edarbi®) therapy on blood pressure in participants with overweight or obesity in routine clinical practice of hypertension (HTN) treatment in the Russian Federation and in the Republic of Kazakhstan..
The drug being tested in this study is called azilsartan medoxomil (Edarbi®). Azilsartan medoxomil is being tested to treat people who have hypertension. This study looks at the clinic systolic and diastolic blood pressure (SBP, DBP) in obese participants who were prescribed azilsartan medoxomil by physicians. The study enrolled 1945 patients. All participants were asked to take azilsartan medoxomil as prescribed by their physician according to local SmPC. This multi-center trial was conducted in the Russian Federation and the Republic of Kazakhstan. The overall duration of study for observation was approximately 6 months. Participants made multiple visits to the clinics as assigned by each physician according to their routine practice, in every 3 months.
Study Type
OBSERVATIONAL
Enrollment
1,945
Azilsartan medoxomil tablets
Change From Baseline in Clinic Systolic Blood Pressure (SBP) at Month 6
The change in clinic sitting SBP measured at Month 6 relative to baseline.
Time frame: Baseline and Month 6
Change From Baseline in Clinic Diastolic Blood Pressure (DBP) at Month 6
The change in clinic sitting DBP measured at Month 6 relative to baseline.
Time frame: Baseline and Month 6
Percentage of Participants With Response at Month 6
Response was defined as a decrease of SBP ≥20 mm Hg or a decrease of DBP ≥10 mm Hg.
Time frame: Month 6
Percentage of Participants Who Achieved Target Blood Pressure (BP) SBP<140 mm Hg and DBP<90 mm Hg
Time frame: Month 6
Change From Baseline in Clinic Systolic Blood Pressure (SBP) in Subgroups of Participants at Month 6
The change in clinic sitting SBP measured at Month 6 relative to baseline. Subgroups included overweight, obesity I (basic metabolic rate \[BMI\] 30-34.9), class II (BMI 35-39.9) and class III (BMI ≥ 40), impaired glucose tolerance, normal glucose metabolism, diabetes mellitus (Yes/No), metabolic syndrome, neither diabetes mellitus (DM) nor metabolic syndrome.
Time frame: Baseline and Month 6
Change From Baseline in Clinic Diastolic Blood Pressure (DBP) in Subgroups of Participants at Month 6
The change in clinic sitting DBP measured at Month 6 relative to baseline. Subgroups included overweight, obesity I (basic metabolic rate \[BMI\] 30-34.9), class II (BMI 35-39.9) and class III (BMI ≥ 40), impaired glucose tolerance, normal glucose metabolism, diabetes mellitus (Yes/No), metabolic syndrome, neither diabetes mellitus nor metabolic syndrome.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
JSC Central Clinical hospital
Almaty, Kazakhstan
Research Institute of Cardiology and Internal Diseases
Almaty, Kazakhstan
Kazakh Medical University of Continuing Education
Almaty, Kazakhstan
Central Clinical Hospital
Almaty, Kazakhstan
National Scientific center of oncology and transpontology
Astana, Kazakhstan
Karaganda State Medical Academy
Karaganda, Kazakhstan
Semipalatinsk State Medical Academy
Semey, Kazakhstan
Altay regional cardiological center
Barnaul, Russia
Belgorod Regional Clinical Hospital of St. Joasaph
Belgorod, Russia
Bryansk Regional Cardiological center
Bryansk, Russia
...and 56 more locations
Time frame: Baseline and Month 6
Percentage of Participants Who Achieved Target Blood Pressure (BP) in Subgroups of Participants at Month 6
Target BP was SBP\<140 mm Hg and DBP\<90 mm Hg. Subgroups included BMI, overweight, Obesity I (BMI 30-34.9), class II (BMI 35-39.9) and class III (BMI ≥ 40), impaired glucose tolerance (Yes/No), metabolic syndrome (Yes/No) and diabetes mellitus (Yes/No).
Time frame: Month 6