Central Glutathione Levels in Women With Late Life Depression: a Cross Sectional Pilot Feasibility Study

Inclusion Criteria: Late-life depression population inclusion criteria * Patients in the LLD study arm will be females 60-85 years of age with a general good bill of health * Patients in the LLD study arm will be presenting with mild to moderate MDD. Diagnosis of MDD will be confirmed through a Structured Clinical Interview for DSM-5-TR (SCID) Axis I disorder. * LLD patients will have a Hamilton Depression Rating Scale (17-item version) score between 8-22 * LLD patients if being treated with any antidepressant agent, will be at a minimum of 4 weeks at therapeutic dosage of medication. Healthy control (HC) population inclusion criteria: * HC participants will be females between 60-85 years of age and in good general health * HC participants will have no history of depression. Exclusion Criteria: * A primary diagnosis of any other mental health disorder (including substance dependence, post traumatic stress disorder, obsessive compulsive disorder, bipolar disorder, neurocognitive disorders, personality disorder, etc.) * High risk of suicide as elicited by clinical interview * History of head trauma * History of severe vascular disease or cerebrovascular infarcts * Any history of neurological disease (including Parkinson's disease or seizures) * An ongoing acute episode of systemic inflammatory disease (e.g. rheumatoid arthritis, ulcerative colitis, crohn's disease) * Any contraindications to MRI * Additionally for Healthy Control participants only, a diagnosis of any mental health disorder