Muscle Fatigue and Carbonic Anhydrase Inhibitors

University of British Columbia13 enrolled

Overview

The objective of this research is to assess the effects of acetazolamide and methazolamide on respiratory and limb muscle fatigue development. A fatiguing protocol will be conducted for the respiratory and plantar flexor muscles and the difference in pressure/torque produced by supramaximal nerve stimulation used to assess muscle fatigue between conditions.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Hypoxia

Interventions

AcetazolamideDRUG

250 mg, taken orally three times per day

MethazolamideDRUG

100mg, taken orally two times per day. A placebo pill will be taken between each dose of methazolamide to match the timing of doses and the number of pills between study arms.

PlaceboOTHER

A placebo will be taken three times per day

Eligibility

Sex: MALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age: 18-40 years. * Regularly physically active * Male Exclusion Criteria: * current or ex-smokers * pulmonary function \<80% of predicted * esophageal tumour or ulcer * have had recent (\<6 months) musculoskeletal injury or any surgery to the lower leg * have contraindications to carbonic anhydrase inhibitors (eg. severe or absolute glaucoma, adrenocortical insufficiency, hepatic insufficiency, renal insufficiency, sulfa allergy or an electrolyte imbalance such as hyperchloremic acidosis) * are obese (BMI \>30 Kg/m2) * taking diuretics, blood thinners, or anti-platelet drugs.

Locations (1)

University of British Columbia

Kelowna, British Columbia, Canada

Outcomes

Primary Outcomes

Change in trans-diaphragmatic pressure generation to supramaximal phrenic nerve stimulation following inspiratory threshold loading.

Time frame: Baseline, 1, 5, 10, 20, and 30 minutes following the loading protocol for each arm of the study

Change in plantar flexor muscle group torque generation to supramaximal tibial nerve stimulation following an isometric loading protocol

Time frame: Baseline, 1, 5, 10, 20, and 30 minutes following the loading protocol for each arm of the study

Secondary Outcomes

Maximal inspiratory pressure maneuvers

Time frame: Baseline and immediately following loading protocol

Maximal Voluntary Contraction of the Plantar Flexor Muscle Group

Time frame: Baseline and immediately following the loading protocol

Contraction time and half-relaxation time

Time frame: Baseline, 1, 5, 10, 20, and 30 minutes post loading protocol

Data from ClinicalTrials.gov

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