Microcirculation and Inflammatory Markers in Patients With Resistant, Stages 1/2 Hypertension and Normal Blood Pressure

Daniel Alexandre Bottino75 enrolled

Overview

Nailfold videocapillaroscopy (NVC), Venous occlusion Plethysmography (VOP) and inflammatory biomarkers have been used to study endothelial function in patients with resistant hypertension, stages 1 and 2 hypertension and normotensive. This was a cross-sectional study.

Microcirculation determines peripheral resistance contributing to increased blood pressure. The nailfold videocapillaroscopy (NVC), Venous occlusion Plethysmography (VOP) and biomarkers can be used to evaluate the microcirculation in arterial hypertension (AH). The objective of this study is to analyze the behavior of serum inflammatory markers and study the microcirculation by nailfold videocapillaroscopy (NVC) and Venous Occlusion Plethysmography in patients with resistant hypertension (RH), with stages 1 and 2 hypertension (MMH ) and normotensive (CG). A cross-sectional study with 75 patients has been performed: 25 with resistant hypertension (RH), 25 with stages 1 and 2 hypertension (MMH) and 25 normotensive (CG). All underwent anamnesis, dosage serum markers and conducting NVC, VOP. Hypertensive patients without statin use and with controlled or uncontrolled blood pressure were also analyzed. For the statistical analysis were used: Kruskal -Wallis ANOVA, Dunn test and ANCOVA for correction of confusion factors such as age and BMI.

Study Type

OBSERVATIONAL

Enrollment

Conditions

High Blood Pressure

Eligibility

Sex: ALLMin age: 27 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of controlled High Blood Pressure stages 1 and 2 (blood pressure levels from 140/90 mmHg to 179/109 mmHg) . * Resistant Hypertension (uncontrolled hypertension, with values ≥140/90 mmHg, using three or more antihypertensive drugs of different classes, including a diuretic, or controlled hypertension with four or more drugs). * Normal Blood Pressure. Exclusion Criteria: * Diabetes Mellitus, Types 1 or 2. * Heart Failure. * Myocardial infarction or stroke with less than three months of the event. * Chronic kidney disease. * Use of hormonal or non-hormonal anti-inflammatory drugs. * Recent trauma (less than three months). * Autoimmune diseases. * Infectious processes in activity. * Neoplasia. * Aspirin use (anti-inflammatory dose). * Obesity grade III (Body Mass Index\>40 kg/m2).

Outcomes

Primary Outcomes

Blood Pressure (mmHg)

Hemodynamic Variable

Time frame: 1 day