Evaluation of Serum Amyloid A in Early Diagnosis of Spontaneous Bacterial Peritonitis

Tanta University100 enrolled

Overview

One of the most common and serious complications in decompensated cirrhotic patients (DCPs) is bacterial infection.The most common infections in DCPs are cases of spontaneous bacterial peritonitis (SBP), which account for 40% 70% of cases, followed by urinary tract infections, pneumonia and cellulitis. Serum amyloid A (SAA) and C-reactive protein (CRP) are acute-phase proteins predominantly produced and secreted by hepatocytes. Other cells including lymphocytes, monocytes, and macrophages can also produce these proteins. The induction of SAA and CRP synthesis is triggered by a number of cytokines, chiefly IL-6, which is released from a variety of cell types, but mainly from macrophages and monocytes at inflammatory sites

Increased serum CRP and SAA levels have been found in a number of disorders, including bacterial infections, malignancies tissue injuries and tissue rejection. Therefore, new studies of early diagnosis, prevention and treatment are needed to improve clinical outcomes.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Spontaneous Bacterial Peritonitis

Interventions

serum amyloid A level

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * • Decompansated cirrhosis with ascites, defined by a combination of any of the following: * Laboratory findings * Endoscopic results * Ultrasound * Histology Exclusion Criteria: * Creatinine\>1.5 mg/dl * Other infection e.grespiratory,UTI ,gastrointestinal and skin infection. * Hepatocellular carcinoma * Other extrahepatic malignancy e.g ; chest * Any significant psychiatric illness or other medical comorbidity. * Any degenerative diseases.

Evaluation of Serum Amyloid A in Early Diagnosis of Spontaneous Bacterial Peritonitis

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts