White matter hyperintensity (WMH) has been found to be related with cognitive and emotional dysfunction. A presumed mechanism is that WMH disrupts the structural connectivity within a large-scale brain network, thereby impairing the brain's ability to integrate the neural processes efficiently. It is not yet clear, what the pattern of brain network disruption relates to WMH and how the brain network disruption induced by WMH has an effect on cognition and emotion performance. Using multi-model magnetic resonance imaging (MRI) techniques, we aimed to explore the mechanisms of cognitive decline and depression related with brain network dysfunction in patients with WMH, and to provide objective imaging marker for early diagnosis and prevention of WMH associated cognitive decline and depression.
Study Type
OBSERVATIONAL
Enrollment
200
The 2nd Affiliated Hospital of Zhejiang University, School of Medicine,
Hangzhou, Zhejiang, China
RECRUITINGFazekas Scale of white matter hyperintensity
Time frame: 1 year
Mini-Mental State Examination (MMSE)
Time frame: 1 year
Hamilton Depression Scale (HAMD)
Time frame: 1 year
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