The aims of the present study is to compare oral sulfate solution (OSS) with low-dose polyethylene glycol plus ascorbic acid (2-L PEG/Asc) for bowel cleansing efficacy.
High-quality bowel cleansing is critical to effective colonoscopy. Studies in the past decade have demonstrated that many clinical practices continue to have rates of adequate preparation as low as 60% to 80%. Low-volume preparations for colonoscopy are designed to improve patient tolerability, another important aspect of bowel preparation. In addition, low-volume preparations should ideally not sacrifice efficacy. There are few data comparing the efficacy of available low-volume bowel preparations. In this study, we describe a prospective, single-blind, randomized, controlled trial comparing oral sulfate solution (OSS) (SUPREP, Braintree Laboratories, Braintree, Mass) with low-dose polyethylene glycol plus ascorbic acid (2-L PEG/Asc).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
200
Oral sulfate solution (OSS)
Low-dose polyethylene glycol plus ascorbic acid (2-L PEG/Asc) COOLPREP is a proprietary name of 2-L PEG/Asc.
Seoul St. Mary's Hospital
Seoul, South Korea
Boston Bowel Preparation Scale (BPPS)
Time frame: during colonoscopy
Aronchick scale
Aronchick scale is a commonly used bowel preparation scale to grade the adequacy of cleansing of colonic segments or the entire colon.
Time frame: during colonoscopy
Tolerability by a patient questionnaire using 5-point Likert scale
to assess tolerability of each bowel preparation
Time frame: on arrival at the endoscopy unit before colonoscopy
Safety by measuring hemodynamic and biochemical data
Biochemical data will be measured only in case of necessity such as weakness, mental change or numbness.
Time frame: at baseline (in the clinic be- fore booking the colonoscopy) and on arrival at the en- doscopy suite
Colonoscopic finding: whether there is erythematous mucosal change or apthous ulcers
Time frame: during colonoscopy
Percentage of cecal intubation
Time frame: during colonoscopy
Insertion time
Time frame: during colonoscopy
Withdrawal time
Time frame: during colonoscopy
Adenoma detection rate
Time frame: during colonoscopy
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