Sympathetic Mapping/ Ablation of Renal Nerves Trial

Inclusion Criteria: 1. Male and non-pregnant female subjects, 18≤age≤65 2. Essential hypertension 3. Office systolic blood pressure ≥150mmHg and ≤180mmHg; and resting heart rate ≥70 bpm without taking beta blocker(Resting heart rate does not taken into account if beta blocker is taken) 4. Average 24-hour ABPM systolic blood pressure ≥130mmHg, or ABPM systolic blood pressure during daytime ≥ 135mmHg, or ABPM systolic blood pressure during nighttime ≥ 120mmHg 5. History of hypertension is longer than 6 months 6. Patient with poor blood pressure control after 6 months of antihypertensive drug therapy, understands the purpose of this study, and is willing to participate and sign the Informed Consent; then the patient receives standard antihypertensive drug treatment (at least two drugs) for at least 28 days, drug compliance ≥80%, office systolic blood pressure ≥150 mmHg and ≤180 mmHg. 7. Patient is compliant and willing to complete clinical follow-up. Exclusion Criteria: 1. Renal artery anatomy is unqualified including： (1) diameter \<4mm or treatable length \<25mm， (2) multiple renal arteries and the main renal artery supplies a fraction of the blood flow less than 75%, (3) renal artery stenosis \>50% or any renal artery aneurysms on either side, (4) history of renal artery PTA, including balloon angioplasty and stenting. 2. eGFR \<45mL/min/1.73m2 (MDRD formula) 3. Hospitalized within one year due to hypertensive crisis 4. Average 24-hour systolic blood pressure \<130mmHg and ABPM systolic blood pressure during daytime ≤ 135mmHg, and ABMP systolic blood pressure during nighttime ≤ 120mmHg 5. Pulse pressure \>80mmHg 6. During running in period, using antihypertensive drugs other than standardized antihypertensive drugs 7. Participated other clinical trials including both drug and medical device studies within 3 months from current study 8. Female with pregnant or lactating, or having plans for pregnancy within 1 year 9. Patient with sleep apnea who needs chronic oxygen-breathing or mechanical ventilation support (for example, tracheostomy) 10. Patients previously or currently suffering from following diseases: (1) essential pulmonary arterial hypertension, (2) type I diabetes, (3) patients with severe cardiac valvular stenosis who have contradictions and cannot rolerant to significantly reduce blood pressure, (4) within half year, patients had myocardial infraction, unstable angina, syncope or cerebrovascular accidents, (5) history of primary aldosteronism, pheochromocytoma, aorta stenosis, hyperthyroidism or hyperparathyreosis, (6) any disease conditions interfering the measurement of blood pressure (for instance, severe peripheral artery diseases, abdominal artery aneurysm, hemorrhagic disorders such as thrombocytopenia, hemophilia and severe anemia), (7) plans to have surgery or cardiovascular interventions within 6 months, (8) alcohol abuse or unknown drug dependence history, (9) neuroticisms such as depression or anxiety disorders, (10) non-compliant patients who are unable to follow the study protocol per physician's requests. 11\. Any contradictions to conduct renal artery stimulation and ablation