Investigation of Hypermobility, Biomarkers, and Pain Generators in Chronic Pain Patients

Inclusion Criteria: * Clinical diagnosis of axial back pain (neck, mid-back, lower back) or pain radiating to the extremity, with suspected diagnosis of a specific pain generator amenable to a pain procedure, including disorders of the nerves, joints, and muscles as listed immediately below. * Clinical decision to schedule patient for a pain procedure, including procedures targeting the following disorders: * Facet arthropathy: intra-articular facet joint injection, medial branch block, medial branch radiofrequency ablation * Sacroiliac joint dysfunction: sacroiliac joint injection, lateral branch block, lateral branch radiofrequency ablation * Myofascial pain syndrome: trigger point injection * Radiculopathy, spinal stenosis, or herniated nucleus pulposus: epidural steroid injection, selective nerve root block * Piriformis syndrome: piriformis injection * Greater trochanteric bursitis: greater trochanteric bursa injection * Able to provide HIPAA authorization to share prior medical records/imaging. Exclusion Criteria: * Previous diagnosis of cancer. * Currently pregnant. * Previously enrolled for the same procedure or the same pain generator site. (For example, this would exclude a patient who had an intra-articular facet joint injection at the right L5/S1 if: 1) he had the same injection 3 months ago and was enrolled at that time, or 2) the patient was already enrolled for a medial branch block at the right L5 and sacral ala, as this targets the same facet joint.) * Inability or unwillingness of subject or legal guardian/representative to give informed consent (e.g., ward of the state)