The existing DBS setting in patients with DBS of the globus pallidus interna (GPi), which aims to treat motor symptoms by a high-frequency stimulation, will be temporarily reprogramed to stimulate the NbM at a low frequency using the distal electrodes positioned in the vicinity of the NBM. This study aims to investigate the neuropsychological effect of low frequency stimulation of the nucleus basalis of Meynert (NBM) in advanced Parkinson's disease (PD) patients, who were previously treated with deep brain stimulation (DBS) of the globus pallidus interna (GPi).
The existing DBS setting in patients with GPi DBS, which aims to treat motor symptoms by a high-frequency stimulation, will be temporarily reprogramed to stimulate the NBM at a low frequency using the distal electrodes positioned in the vicinity of the NBM.This study consists of a three-day screening study of the NbM stimulation followed by a two-week, randomized, single-blind, crossover trial. Between the screening study and the crossover trial, one week of washout period will be applied to eliminate potential carryover effect from the previous stimulation. This study aims to investigate the neuropsychological effect of low frequency stimulation of the nucleus basalis of Meynert (NBM) in advanced Parkinson's disease (PD) patients, who were previously treated with deep brain stimulation (DBS) of the globus pallidus interna (GPi).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
13
Changes in global cognitive function measured by the Scales for Outcomes in Parkinson's disease-Cognition (SCOPA-COG)
Time frame: 2 weeks of the crossover trial phase
Changes of Unified Parkinson's Disease Rating Scale (UPDRS) part 3
Time frame: 3 days of the screening phase
Changes of the power of background EEG frequencies
Time frame: 2 weeks of the crossover trial phase
Score changes of stroop test
Time frame: 2 weeks of the crossover trial phase
Score changes of the Trail Making test
Time frame: 2 weeks of the crossover trial phase
Score changes of the digit span test of Wechsler Adult Intelligence Scale III
Time frame: 2 weeks of the crossover trial phase
Score changes of the symbol digit modality test (SDMT)
Time frame: 2 weeks of the crossover trial phase
Score changes of the Hospital Anxiety and Depression Scale
Time frame: 2 weeks of the crossover trial phase
Score changes of the Apathy Evaluation Scale
Time frame: 2 weeks of the crossover trial phase
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