Background: Nebulizers design influences efficiency of aerosol delivery. Performance of nebulizers is commonly tested by breathing simulators with static parameters. However, breathing patterns vary in adults. Objectives: The purpose of this study was to evaluate drug deposition of different types of nebulizers testing with breathing patterns of healthy subjects.
Material and Methods The study was approved by Chang Gung Memorial Foundation Institutional Review Broad. Ten healthy subjects, aged 20.6±0.5 years, were recruited. Four nebulizers: 1. a constant jet nebulizer (Neb-easy, Galemed Corp., Taiwan); 2. a breath enhanced nebulizer (Pari LC plus, Pari Inc., Germany); 3. a manual-actuated nebulizer (A-T Neb, Atlantean Corporation, Taiwan); and 4. a breath-actuated nebulizer (AeroElipes, Trudell Medical Inc, Canada) were evaluated.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Enrollment
10
A constant jet nebulizer (Neb-easy, Galemed Corp., Taiwan) was tested with salbutamol sulfate powered by compressed gas flow at 6 L/min.
A breath enhanced nebulizer (Pari LC plus, Pari Inc., Germany) was tested with salbutamol sulfate powered by compressed gas flow at 6 L/min.
A manual-actuated nebulizer (A-T Neb, Atlantean Corporation, Taiwan) was tested with salbutamol sulfate powered by compressed gas flow at 6 L/min.
Inhaled and exhaled drug concentrations
Drug deposited on the collecting filter was analyzed.
Time frame: Drug deposition was tested Immediately after each nebulization, expected average of 20 minutes
Breathing parameters
Minute ventilation was recorded during nebulization
Time frame: During each nebulization testing, an expected average of 10 minutes
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A breath-actuated nebulizer (AeroElipes, Trudell Medical Inc, Canada) was tested with salbutamol sulfate powered by compressed gas flow at 6 L/min.