There are two commonly used treatment strategies for treating patients who have chronic migraine with medication overuse. This study will compare the outcomes amongst patients randomized to one of the two treatment strategies.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
720
Start of new migraine preventive therapy or adjustment of current preventive therapy without immediate discontinuation of the overused medication(s)
Immediate discontinuation of the overused medication(s) and the start of new migraine preventive therapy or adjustment of current preventive therapy
Frequency of Moderate to Severe Headache Days
Number of days on which a headache lasts for at least 2 hours and at any time peaks at moderate or severe intensity
Time frame: 12 weeks
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Northern Arizona Healthcare Medical Group
Flagstaff, Arizona, United States
Mayo Clinic in Arizona Headache Center
Phoenix, Arizona, United States
Mayo Clinic in Arizona Neurology Center
Phoenix, Arizona, United States
Honor Health Neurology
Scottsdale, Arizona, United States
Mayo Clinic Thunderbird
Scottsdale, Arizona, United States
Keck Medical Center of USC
Los Angeles, California, United States
University of Colorado Denver Headache Center
Aurora, Colorado, United States
University of Colorado Denver Primary Center
Denver, Colorado, United States
Blue Sky Neurology
Greenwood Village, Colorado, United States
Memorial Healthcare
Hollywood, Florida, United States
...and 19 more locations