Comparison of Skin Prick Testing Results of Local and Imported Pollen Allergen Extracts and Specific IgE

Mahidol University68 enrolled

Overview

Pollen allergen extracts are prepared locally and checked for efficacy by comparison to imported allergens and specific IgE.

Skin prick test (SPT) and specific IgE (sIgE) are approved for evaluation of allergen sensitization. Local allergen extracts are cheaper and more available but need standardization. Pollen allergen extracts: Bermuda, Johnson and careless weed are locally prepared and compared mean wheal diameter of skin prick test to imported allergens and also to specific IgE.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Immediate Type Hypersensitivity

Interventions

Pollen sensitizationBIOLOGICAL

Skin prick test with local and imported Bermuda, Johnson and careless weed allergen extracts at concentration of 10,000, 3,000, 1,000 and 300 AU/mL and measure specific IgE levels

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Positive skin prick test to Bermuda or Johnson or careless weed Exclusion Criteria: * Chronic diseases such as heart disease, liver, renal and severe sepsis * Severe allergic symptoms such as anaphylaxis * Extensive skin rashes * Pregnancy

Outcomes

Primary Outcomes

Mean wheal diameter of local and imported grass and weed pollens

compare mean wheal diameter of skin prick test of different concentration among local, imported allergen extract and specific IgE levels of Bermuda grass, Johnson grass and careless weed

Time frame: 18 months

sIgE levels of Bermuda grass,Johnson grass and careless weed

Measure level of sIgE of Bermuda grass,Johnson grass and careless weed and compare to SPT results

Time frame: 18 months

Data from ClinicalTrials.gov

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