Green Coffee Extract and Metabolic Syndrome

National Nutrition and Food Technology Institute43 enrolled

Overview

Metabolic syndrome (Mets) is an assemblage of risk factors which can increase the risk of developing type 2 diabetes mellitus and cardiovascular disease. Green coffee extract (GCE) is derived from unroasted coffee beans and has substantial amounts of polyphenols primarily chlorogenic acids (CGA). It has been shown that GCE and CGA can exert a positive influence over Mets components including blood pressure, blood glucose, inflammation, oxidative stress, insulin resistance and blood lipids. Up to our knowledge no study has been conducted on humans in the field of GCA influences on Mets patients. Therefore, this study is planned to evaluate GCA supplementation effects on anthropometric measurements, glycemic control, blood pressure, lipid profile in patients with metabolic syndrome.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Metabolic Syndrome

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Waist circumference\>102 cm in men and \>88 cm in women * Fasting blood glucose\>100 mg/dL (5.6 mmol /L) * Systolic blood pressure\>130 mmHg or diastolic blood pressure\>85mmHg * Triglycerides\> 150 mg/dL (1.7 mmol/L) Exclusion Criteria: * Insulin administration * Pregnancy and breastfeeding * regular consumption of coffee and green tea

Outcomes

Primary Outcomes

fasting blood glucose

Time frame: 8 weeks

Secondary Outcomes

HOMA-IR

Time frame: 8 weeks

blood pressure

Time frame: 8 weeks

insulin

Time frame: 8 weeks

hemoglubin A1c

Time frame: 8 weeks

triglyceride

Time frame: 8 weeks

Green Coffee Extract and Metabolic Syndrome

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes