Propolis Effects in Patients With Chronic Kidney Disease

University of Sao Paulo General Hospital32 enrolled

Overview

The aim of this study is to determine the impact of Propolis on proteinuria reduction and protection of the glomerular filtration rate in chronic renal failure patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Chronic Kidney Diseases

Interventions

PropolisDRUG

Patients will receive 500 mg / day of the propolis extract in the form of tablets split in two daily doses

PlaceboDRUG

Patients will receive 500 mg / day of the placebo in the form of tablets split in two daily doses

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * older than 18 years; * less than 90 years; * glomerular filtration rate between 25 and 70 ml / min; * proteinuria in the urine 24 hours more than 300 mg or protein / creatinina in isolated urine greater than 0.3g / g or microalbuminuria (albumin / creatinine ratio) between 30-300 mg / g. Exclusion Criteria: * Pregnants; * Neoplasia carrier; * Renal transplant patients; * Patients who refuse to participate in the study. * Glomerulopathy on Immunosuppression

Locations (1)

University of Sao Paulo General Hospital

São Paulo, Brazil

Outcomes

Primary Outcomes

Reducing Proteinuria

Reduction from baseline proteinuria.

Time frame: One year

Secondary Outcomes

Protection of the glomerular filtration rate

Maintaining glomerular filtration rate or inferior reduction to 5 ml per minute per 1.73 m2 of body-surface area from baseline.

Time frame: One year

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.