Effects of Propofol and Sevoflurane on Early POCD in Elderly Patients With Metabolic Syndrome

General Hospital of Ningxia Medical University94 enrolled

Overview

The purpose of this study is to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.

By now, a series risk factors of cardiovascular diseases, which are also related to the development of postoperative cognitive dysfunction (POCD), are becoming more common.The investigators don't know whether propofol based anesthesia has a more severe impact on early postoperative cognitive function than sevoflurane in elderly patients with metabolic syndrome. In this study, the investigators want to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Postoperative Complications

Interventions

metabolic syndromeOTHER

metabolic syndrome

Eligibility

Sex: ALLMin age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * aged ≥60 years; * ASAⅡor Ⅲ * noncardiac surgery and nonneural surgery Exclusion Criteria: * Mini Mental State Examination \[MMSE\] score too low * chronic alcoho and drug abuse * disturbed renal and liver function * history of a cerebrovascular accident * permanent ventricular pacing * preoperative cognitive deficits * lack of cooperation

Outcomes

Primary Outcomes

Number of participants with Postoperative cognitive dysfunction (POCD) as assessed by Mini-Mental State Examination (MMSE) score in propofol group and sevoflurane group

Time frame: up to 7days postoperatively

Data from ClinicalTrials.gov

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