Hepatic Arterial Infusion Chemotherapy(HAIC) for Hepatoma After Resection

Inclusion Criteria: * 18 years and older * Informed consent Confirmation of diagnosis of HCC: For subjects undergoing surgical resection histological confirmation is mandatory (a post surgery pathology report is required for both histological confirmation and risk stratification). * After qualifying at the time of scanning, by independent radiology review diagnosed CR (no residual tumor deposit radical therapy Assess their level of risk of disease recurrence by tumor characteristics as moderate or high risk * Subjects who have undergone surgical resection for treatment of HCC with curative intent within 4 months from staging to potentially curative treatment. * At least 3 weeks (21 days) but not more than 7 weeks (49 days), from resection course, to CT/MRI scan date. A timeframe of 4 weeks after surgical resection is recommended. * Male or female subjects ≥ 18 years of age Confirmation of complete response(CR)- (absence of residual tumor after curative treatment), on the eligibility scan by independent radiological review. * For subjects undergoing surgical resection pathology proven complete removal of tumor. Intermediate or High Risk of recurrence as assessed by tumor characteristics. * Child-Pugh score 5 -7 points. A Child-Pugh score of 7 points is allowed only in the absence of ascites. * Eastern Cooperative Oncology Group (ECOG) Performance Status of 0. * Adequate bone marrow, liver and renal function as assessed by central lab by means of the following laboratory requirements from samples within 14 days prior to randomization: Alpha fetoprotein ≤ 400 ng/mL * Women of childbearing potential must have a negative serum pregnancy test performed within 14 days prior to the start of treatment (assessed centrally). Exclusion Criteria: * Recurrent HCC Child-Pugh score 7 points with presence of ascites. * The following tumor characteristics: Low risk of recurrence after curative treatment defined as any of the following: for local ablation patients: single lesions ≤ 2 cm for surgical resection patients: single lesions ≤ 2 cm without microscopic vascular invasion, without tumor satellites and histologically well differentiated. ≥ 3 lesions or 2-3 lesions of which any are ≥ 3 cm in size (largest diameter, unidimensional measurement) prior curative treatment (surgical resection or local ablation) single lesion ≥ 5 cm (largest diameter, unidimensional measurement) in size prior local ablation. * Macrovascular invasion Extrahepatic spread (including regional lymph nodes and invasion into adjacent structures) * History of cardiovascular disease: * History of HIV infection Active clinically serious infections (≥ grade 2 NCI-CTCAE version 3.0) * Subjects with seizure disorder requiring medication (such as steroids or anti-epileptics) * History of organ allograft Subjects with evidence or history of bleeding diathesis * Subjects undergoing renal dialysis * Previous or concurrent cancer that is distinct in primary site or histology from the cancer being evaluated in this study EXCEPT cervical carcinoma in situ, treated basal cell carcinoma, superficial bladder tumors \[Ta, Tis \& T1\] or any cancer curatively treated ≥ 3 years prior to study entry as defined by the signing of informed consent. * Uncontrolled ascites (defined as not easily controlled with diuretic treatment) * Encephalopathy History of GI bleeding within 30 days of randomization. * Subjects with a history of esophageal varices bleeding which has not been followed by effective therapy and/or treatment to prevent bleeding recurrence. * Prior anti cancer therapy for treatment of HCC (including sorafenib or any other molecular therapy) is excluded. * Major surgery within 4 weeks of start of study as defined by the signing of informed consent, except for surgical resection or local ablation of HCC. * Autologous bone marrow transplant or stem cell rescue within 4 months of study entry as defined by the signing of informed consent. * Use of biologic response modifiers, such as colony stimulating factor(G-CSF), within 3 week of study entry, as defined by the signing of informed consent. * Investigational drug therapy outside of this trial during or within 4 weeks of study entry, as defined by the signing of informed consent. * Pregnant or breast-feeding subjects. * Substance abuse, medical, psychological or social conditions that may interfere with the subject's participation in the study or evaluation of the study results * Known or suspected allergy to contrast media for angiography. * Any condition that is unstable or could jeopardize the safety of the subject and their compliance in the study * This applies to subjects with severe obstruction of the upper GI tract that require gavage.