Decision-making for treatment of metastatic breast cancer after the second line of chemotherapy was limited by the lack of established predictive factors of benefit for further chemotherapy regimens. Eribulin has emerged as the only single agent demonstrating an overall survival improvement in the third-line setting or beyond. The purpose of this study was to define the clinical profile of metastatic breast cancer participants achieving long-term benefit from chemotherapy with eribulin in the third-line setting or beyond.
This was a multicenter, retrospective, observational, case study analysis to assess long-term eribulin treatment in metastatic breast cancer. The study was conducted in 26 Spanish hospitals participating in a national pre-market access program to eribulin between 2011 and 2014. An exploratory comparison with a group of short-term responders included in a similar observational study was performed.
Study Type
OBSERVATIONAL
Enrollment
45
Unnamed facility
Santiago de Compostela, A Coruña, Spain
Unnamed facility
Las Palmas de Gran Canarias, Gran Canaria, Spain
Unnamed facility
San Sebastián, Guipuzcoa, Spain
Overall survival
Time frame: up to 7 months
Progression free survival (PFS)
Time frame: up to 7 months
Objective response rate
Time frame: up to 7 months
Time to response
Time frame: up to 7 months
Post progression survival
Time frame: up to 7 months
Number of participants with adverse events/serious adverse events/toxic deaths as a measure of safety
Time frame: up to 7 months
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Unnamed facility
Barbastro, Huesca, Spain
Unnamed facility
Alcorcón, Madrid, Spain
Unnamed facility
Aravaca, Madrid, Spain
Unnamed facility
Pozuelo de Alarcón, Madrid, Spain
Unnamed facility
Pamplona, Navarre, Spain
Unnamed facility
Bilbao, Vizcaya, Spain
Unnamed facility
Badajoz, Spain
...and 11 more locations