Evaluation of efficacy and safety from 6hours of 7 cmH2O CPAP after weaning in patients undergoing lung resection, on the prevention of atelectasis / pneumonia and gas exchange improve.
Multicenter randomized clinical trial. 460 patients randomly assigned to treatment and control groups will be studied. The main variables are the frequency of atelectasis or pneumonia, defined by clinical and radiological criteria, the FiO2/PaO2 ratio, 7 and 24 h after weaning, and hospital stay.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
258
Hopsital universitario La Princesa
Madrid, Madrid, Spain
HGU Gregorio Marañón
Madrid, Madrid, Spain
H. Ramón y Cajal
Madrid, Madrid, Spain
HU 12 de octubre
Madrid, Madrid, Spain
Frequency of atelectasis- Pneumonia, and other postoperative complications,
Time frame: 1 week after the surgical intervention
Gas exchange ( Pa/FiO2)
Time frame: 1 week after the surgical intervention
Hospital stay comparison between arms
Time frame: from the surgical intervention date to hospital discharge date up to 1month
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