Therapeutic Effect of Colla Corii Asini on Improving Anemia and Hemoglobin Composition in Pregnant Women With Thalassemia

Inclusion Criteria: * pregnant women diagnosed as thalassemia carriers by genetic test with clinical presentation of minor or intermediate β- thalassemia; * patients with mild anemia (80 g/L≤ Hb\<110 g/L) prior to study enrollment; * singleton pregnancy; * patients having not received blood transfusion or any forms of anti-anemia treatment in Western Medicine or Traditional Chinese Medicine in the last 12 weeks; * informed consent obtained. Exclusion Criteria: * patients with severe thalassemia; * patients with severe anemia (Hb\<80 g/L) prior to study enrollment; * twin or multiple pregnancies; * patients with any of the following abnormalities: immunodeficiency, primary diseases involving cardiovascular system, liver, kidney, gastrointestinal tract, endocrine system and hematological system; * allergic to two or more drugs; * patients with mental illness or poor compliance to medical treatment; * patients having received blood transfusion or any forms of anti-anemia treatment in Western medicine or Traditional Chinese Medicine in the last 12 weeks; * no informed consent obtained.