A Study of Apatinib for Advanced Hepatocellular Carcinoma Patients After First-line Treatment Failure

Inclusion Criteria: * Patients with a histologic or cytologic diagnosis of hepatocellular carcinoma, imaging diagnosis should be compatible with chinese standard for diagnosis and treatment of primary liver cancer (Edition 2011) * Have progressed after systematic chemotherapy/target therapy, or cannot tolerated with first-line treatment, and have at least one measurable lesion. according to RECIST 1.1, the long diameter of measurable lesion should be more or equal than 10mm, or the short diameter of a enlarged lymph node should be more or equal than 15mm, the maximum diameter of a viable tumor should be no more than 15cm * The previous chemotherapy and the present trial registration must be at least 2 weeks apart. And they must have recovered from any toxicity of a previous chemotherapy * Patients with Child Pugh Class A \& B disease are eligible for the study * Patients with Barcelona Clinic Liver Cancer stage B or C are eligible for the study * Eastern Cooperative Oncology Group performance score (PS): 0-2 * Life expectancy of at least 12 weeks * Hepatitis B virus DNA\<2000 IU/ml * Adequate organ function meeting the following: * Bone marrow: absolute neutrophil count ≥1.5×109/L (1500/mm3); platelet ≥ 75×109/L; hemoglobin ≥9 g/dL * Liver: Serum bilirubin ≤ 1.5 ×ULN, AST and ALT ≤ 5 ×ULN, ALB ≥ 29 g/L * Kidney: Cr ≤1.5 ×upper limit of normal * Within 7 days prior to the start of therapy, women of child-bearing potential must undergo a pregnancy test, which must be negative; men of child-bearing potential: contraceptive measures must be adopted during treatment and within 8 weeks afterward * Subjects who understand and voluntarily signed a written informed consent form Exclusion Criteria: * Diagnosed with cholangiocellular carcinoma, mixed cell carcinoma and fibrolamellar hepatocellular carcinoma * History of other malignancy within 5 years except for non-melanoma skin cancer, cervix in situ carcinoma * Prepared for liver transplantation * Patients with contraindications (active bleeding, ulcers, intestinal perforation, intestinal obstruction, within 30 days after major surgery, uncontrolled high blood pressure medication, III-IV level cardiac insufficiency, severe liver and kidney dysfunction) * A previous history of Interstitial pulmonary disease, drug-induced interstitial disease, radiation pneumonitis requiring hormonal therapy or active interstitial lung disease with any clinical evidence * Use of CYP3A4 inhibitor within 7 days or CYP3A4 inducer within 12 days prior to enrollment * Patients with central nervous system metastases or brain metastasis * Previous definite diagnosis of neuropsychiatric disturbances, including epilepsy or dementia * Pregnant or lactating women * Patients with bone metastasis received palliative radiation within 4 weeks prior to enrollment