3 Month Outcome of Ziv-aflibercept for DME

Inclusion Criteria: * Patients with central diabetic macular edema * Best corrected visual acuity is 20/25 or less * Central macular thickness more than 250 microns * Patients who are able to come for all follow-up Exclusion Criteria: * Significant renal disease, defined as a history of chronic renal failure requiring dialysis or kidney transplant. * Myocardial infarction, other acute cardiac event requiring hospitalization, stroke, transient ischemic attack, or treatment for acute congestive heart failure within 4 months prior to randomization * For women of child-bearing potential: pregnant or lactating or intending to become pregnant within the next 3 years. * Macular edema is present that is considered to be related to ocular surgery such as cataract extraction * Substantial cataract that, in the opinion of the investigator, is likely to be decreasing visual acuity by 3 lines or more * History of major ocular surgery (including vitrectomy, scleral buckle, any intraocular surgery, etc.) within prior 4 months or anticipated within the next 6 months following randomization. * Exam evidence of severe external ocular infection, including conjunctivitis, chalazion, or substantial blepharitis