Effect of Antioxidant Intake on Resistin Levels In Patients With Gum Disease and Diabetes

Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre40 enrolled

Overview

To evaluate the effectiveness of non surgical periodontal therapy in addition to antioxidant(ALA) on resistin levels in patients with type 2 diabetes and periodontal disease

A total of 40 patients with diabetes and chronic periodontitis attending the department of periodontics will be recruited in the study. 40 subjects will be randomly divided into two groups(control group and test group with 20 subjects in each group). Clinical parameters such as gingival index, periodontal index, random blood sugar levels(RBS) and glycosylated hemoglobin levels (Hb1aC) will be recorded at baseline and after 3 months and 2ml of blood sample will be collected by venepuncture ( baseline and after 3 months) and stored in Ethylenediaminetetraacetic acid containing vials to identify the levels of resistin in the patients by Enzyme linked immunosorbent assay. Group A will receive Alpha lipoic acid at baseline for a period of 3 months. Both the groups will receive scaling and rootplaning at baseline.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

SINGLE

Enrollment

Conditions

Diabetes Mellitus Periodontitis

Interventions

Alpha lipoic acidOTHER

Scaling and root planing will be done at baseline and systemic antioxidant Alpha lipoic acid 1800mg/day in 3 divided doses for a period of 3 months.

Scaling and Root planingPROCEDURE

Scaling and root planing will be done at baseline.

Eligibility

Sex: ALLMin age: 35 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: Diabetic patients with Chronic periodontitis. \- Exclusion Criteria: Smokers, Pregnant \& lactating women, Prior periodontal therapy within 3 months.

Locations (1)

Mohans Diabetic Centre

Hyderabad, Telangana, India

Outcomes

Primary Outcomes

Serum Resistin Levels and HBAIC Levels

2ml of blood sample will be collected by venepuncture at baseline and after 3 months and will be assessed by ELISA stored in EDTA containing vials to identify the levels of resistin in the patients by ELISA. Glycosylated hemoglobin levels (Hb1aC) will be recorded at baseline and after 3 months and assessed by Spectrophotometer.

Time frame: 3 months

Secondary Outcomes

Gingival Index

Gingival index was recorded with william's periodontal probe at baseline and after 3 months

Time frame: 3 months

Probing pocket depth

Were recorded with william's periodontal probe at baseline and after 3 months

Time frame: 3 months

Clinical Attachment levels

Were recorded with william's periodontal probe at baseline and after 3 months

Time frame: 3 Months

Data from ClinicalTrials.gov

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