Association Between Telomere Length and Risk of Acute Coronary Syndrome

Air Force Military Medical University, China400 enrolled

Overview

Compelling epidemiological evidence indicates that alterations length of telomere, are associated with the initiation and development of ischemic heart disease. This study was undertaken to investigate whether mtDNA copy number in peripheral blood leukocyte could be used as a risk predictor for acute coronary syndrome.

Study Type

OBSERVATIONAL

Enrollment

400

Conditions

Acute Coronary Syndrome

Eligibility

Min age: 18 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: -1.History of documented myocardial infarction; 2.Prior coronary revascularization intervention (coronary artery bypass graft surgery or percutaneous coronary intervention); 3.The presence of≥50% stenosis in one or more coronary arteries identified during cardiac catheterization; Exclusion Criteria: -1.History of malignancy or end-stage renal disease; 2.Blood transfusion within one month or prior bone marrow transplantation 3.Patients who reluctant to sign informed consent

Locations (1)

Xijing Hospital

Xi'an, Shaanxi, China

Outcomes

Primary Outcomes

Relative telomere length

the ratio of telomere repeat copy number(T) to the hemoglobin(HGB) copy number (S) was determined for each sample using standard curves. The derived T/S ratio was proportional to the relative telomere length(RTL). In the second step, the T/S ratio of each sample was normalized to a calibrator DNA to standardize between different PCR runs. The calibrated T/S ratio was then used as the measurement of RTL in this study.

Time frame: From date of percutaneous coronary intervention until the date of discharging from hospital, assessed up to 5 days

Data from ClinicalTrials.gov

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