Comparison of Serological Test s for the Virus Chicken Pox Virus (VZV) and Correlation With the Patient's Memory of the Infection or Vaccination

Hopital Foch308 enrolled

Overview

Comparison of the sensibility and specificity of 3 different serological tests and evaluation of chicken pox immunity in pregnant women. Secondary goals : * Correlation memory / Immunity; * Prevalence of VZV immunity in pregnant women; * Evaluation of cellular and humoral immunity in cases with discrepancy between tests or between test and memory; * Evaluation of acceptability of vaccination in the post partum period in non immune patients. Methods Not randomized prospective study, Number of patients : 400 Duration : 36 months Inclusion criteria : pregnant women \>18years old, agree to participate (written consent) Exclusion criteria: auto immune disease, HIV +, grafted patients

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

308

Conditions

Pregnancy

Interventions

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Pregnant women aged over 18 * Affiliated to a social protection scheme or women benefiting from such a regime * Women who gived a writing consent Exclusion Criteria: * Women with a maternal disease: autoimmune disease (systemic lupus erythematosus, antiphospholipid syndrome, insulin dependent diabetes, autoimmune thyroiditis ..), it takes an immunosuppressive treatment or not. * HIV-positive women * Garfted women whatever organ

Outcomes

Primary Outcomes

Rate sensitivity and specificity in negative and dubious zone for the assessment of the serology of anti VZV immunity

Time frame: 35 weeks

Secondary Outcomes

frequency of immunity detecting depending on whether the patient remember having varicella, have been in contact with next of kin with varicella or been vaccinated against varicella or not

Time frame: up to 35 weeks

Percentage of women accepting the vaccination in case of negative history

Time frame: day during the first visit