The purpose of this study is to determine whether patients with epilepsy exhibiting impaired dCA, which may contribute to subsequent stroke.
The relationship between epileptic seizures and cerebrovascular disease is complex, ranging from mechanisms to clinical manifestation. Stroke is one of the most common causes of epilepsy in adulthood. It was also reported that patients with epilepsy exhibited a higher risk of stroke. But its potential mechanism was never fully understood. Dynamic cerebral autoregulation(dCA), a mechanism to maintain the cerebral bold flow, has been proved to be critical for the occurrence ,development and prognosis of ischemic neurovascular disease. In this study, we hypothesis that impaired dCA play a role in epilepsy and subsequent stroke.
Study Type
OBSERVATIONAL
Enrollment
200
First Hospital of Jilin University
Changchun, Jilin, China
phase difference(PD) in degree
A dynamic cerebral auto-regulation parameter derived from transfer function analysis.Continuous cerebral blood flow velocities of bilateral middle cerebral artery will be assessed noninvasively using transcranial Doppler. Spontaneous arterial blood pressure will be simultaneously recorded using a servo-controlled plethysmograph on the left or right middle finger with an appropriate finger cuff size. Transfer function analysis will be used to derive the autoregulatory parameters.
Time frame: 1 year
the rate of recovery of cerebral blood flow velocity
A dynamic cerebral auto-regulation parameter derived from transfer function analysis.The details are same as primary outcome
Time frame: 1 year
gain in cm/s/mmHg
A dynamic cerebral auto-regulation parameter derived from transfer function analysis.The details are same as primary outcome
Time frame: 1 year
the consequence of electroencephalograph（EEG）
Time frame: 1 year
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