PRP Gel in Wound Closure in Recurrent CS

Ain Shams University128 enrolled

Overview

There is limited application of the use of PRP in obstetrics, therefore there is a need for assessment if it is efficacy in improving skin wound healing in cesarean section.

This study aims to assess the efficacy of injection of platelet rich plasma into the wound of recurrent cesarean section for improving wound healing and enhancing the shape of the wound in women undergoing cesarean section.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

128

Conditions

Previous Incision Scar; Previous Cesarean Section

Interventions

platelet rich plasma gelBIOLOGICAL

Platelet rich plasma is prepared from fresh whole blood which is collected from a peripheral vein stored in acid citrare dextrose solution A (ACD-A)anticoagulant and processed to increase platelets by separating various components of blood

salineBIOLOGICAL

64 controlled women with recurrent cesarean section and fullfit to all inclusion and exclusion craiteria will reseve saline injection at time of wound closure

Eligibility

Sex: FEMALEMin age: 25 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * elective cesarean section * Body mass index 18:25 * Hemoglobin more than 10.5 g/d * Albumin within normal more than or equal 3.5 g/d Exclusion Criteria: * medical disorders(Diabetes mellitus,heart disease,hypertension,systemic lupus erythematosus) * high risk pregnancy as (placenta previa,placenta accreta) * patient on corticosteroids medication * primigravida subjected cesarean section * complicated cesarean section (increased operation time,blood transfusion, drain, scrubbing of multiple surgeons) * cesarean section due to chorioaminionitis * postoperative complication such as:postpartum hemorrhage, paralytic ileus, sever distention..) will be dropped out from the study

Locations (1)

Rasha

Cairo, Cairo Governorate, Egypt

Outcomes

Primary Outcomes

Efficacy of PRP in Wound healing in cesarean section by 100 mm visual analog scale

Efficacy of PRP in Wound healing in cesarean section by 100 mm visual analog scale (VAS) for wound healing

Time frame: one month

Secondary Outcomes

Assessment of the Cosmetic results of the wound by Modified Vancouver scar scale

Time frame: one month

Data from ClinicalTrials.gov

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