Aim of this clinical study is to establish a novel technique, the so called intraoperative fluorescence angiography, for kidney graft perfusion visualization during the transplant procedure.
Additional to the common transplant procedure, measurements of the graft perfusion should be established in two ways. Firstly, each kidney should be measured by a common duplex ultrasound measurement to assess the resistance index (RI) in the three poles of the kidney (upper, middle, lower pole). Secondly, intraoperative fluorescence angiography is going to be performed. Therefore, the camera of the fluorescence angiography system (SPY Elite System, Novadaq, USA) is positioned over the organ, and the fluorescence dye (ICG) is applicated intravenously. The aim will be to correlate the fluorescence angiography findings with the RIs and therefore to establish valuable fluorescence parameters.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
128
perioperative application of Indocyanine green (ICG)
University of Erlangen, Vascular Surgery
Erlangen, Germany
University of Mannheim, General Surgery
Mannheim, Germany
Correlation of intraoperative SPY Perfusion Parameters with short-term outcome of the graft function
The intraoperative fluorescence parameters (Ingress, Ingressrate, Egress, Egressrate) will be correlated with the creatinine level of the first 10 postoperative days.
Time frame: 24 Months
Evaluation of the ideal ICG dosage for intraoperative kidney perfusion
Time frame: 6 Months
Correlation of intraoperative measured resistance indices with fluorescence parameters (Ingress, Ingressrate, Egress, Egressrate)
Time frame: 12 Months
Correlation of graft rejection episodes and fluorescence parameters
Time frame: 24 Months
Correlation of fluorescence parameters with numbers of dialysis needed during the first 10 postoperative days
Time frame: 24 Months
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