The primary objective of the study is to evaluate the real-world clinical effectiveness, as measured by the proportion of participants relapsed at 12 months, in participants treated with dimethyl fumarate (DMF). Secondary objectives of the study are: To evaluate the real-world clinical effectiveness, as measured by the proportion of participants relapsed at 12 months, in participants treated with DMF, glatiramer acetate (GA), teriflunomide, or fingolimod both in the overall participant cohort and in a subset of participants who were naïve to disease-modifying therapy (DMT) and were diagnosed with multiple sclerosis (MS) within 3 years of starting the index therapy; To compare relapse activity, defined as annualized relapse rate (ARR), among participants treated with DMF, GA, teriflunomide, or fingolimod; To compare MS-related hospitalizations among participants treated with DMF, GA, teriflunomide, or fingolimod; To compare intravenous corticosteroid use among participants treated with DMF, GA, teriflunomide, or fingolimod.
Study Type
OBSERVATIONAL
Enrollment
2,978
Research Site
Homewood, Alabama, United States
Research Site
Gilbert, Arizona, United States
Research Site
Hanford, California, United States
Research Site
Modesto, California, United States
Research Site
Santa Ana, California, United States
Research Site
Proportion of participants relapsed at 12 months in participants treated with DMF
Single time point per participant retrospective medical record abstraction with no required study visits or procedures
Time frame: One day
Proportion of participants relapsed at 12 months treated with index therapy in the overall population as well as the subgroup of MS participants who were naïve to DMTs and were diagnosed with MS within 3 years of starting the index therapy
Single time point per participant retrospective medical record abstraction with no required study visits or procedures
Time frame: One day
ARR at 12 months in participants treated with index therapy in the overall population as well as in the matched cohorts
Single time point per participant retrospective medical record abstraction with no required study visits or procedures
Time frame: One day
Proportion of relapsed participants with one or more MS-related hospitalizations during the 12 months following treatment initiation in participants treated with index therapy in the overall population and the matched cohorts
Single time point per participant retrospective medical record abstraction with no required study visits or procedures
Time frame: One day
Proportion of relapsed participants requiring treatment with intravenous corticosteroids during the 12 months following treatment initiation in participants treated with index therapy in the overall participant population and the matched cohorts
Single time point per participant retrospective medical record abstraction with no required study visits or procedures
Time frame: One day
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Aurora, Colorado, United States
Research Site
Danbury, Connecticut, United States
Research Site
Hartford, Connecticut, United States
Research Site
Jacksonville, Florida, United States
Research Site
Port Orange, Florida, United States
...and 111 more locations