Resistant Bacterial Infections in the Early Post LDLT Period

Ain Shams University45 enrolled

Overview

The purpose of this work was to study the incidence, types, risk factors and causative organisms of bacterial infections in HCV Egyptian patients following Liver Transplantation. Moreover, to identify the emerging resistant strains and their proper antimicrobial therapy

This prospective descriptive study has been done at Tropical Medicine department in the period between January 2014 to November 2015. After the approval of the scientific and ethical committee of Ain Shams University Hospital, Patients with HCV positive end stage liver disease (ESLD) eligible for liver transplantation Ain Shams Center for Organ Transplant (ASCOT); Ain Shams University, (fulfilling the inclusion criteria) were included in the current study. Forty five patients were recruited and each one was followed-up during a period of 3 months following transplantation. Included patients were divided into 2 groups: Group 1 included patients who had a postoperative single episode of infection. Group 2 included those patients who had more than 1 episode of postoperative bacterial infection whom were further evaluated for the presence of emerging strains and/or antibiotic resistance.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Transplantation Infection

Interventions

Living donor liver transplantationPROCEDURE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Egyptian nationality. * Accepting participation in the current study and signing a written consent form * Age between 18-60 Years, including males and females. Exclusion Criteria: * Patients who refused to be enrolled in the study. * Patients with other etiologies for end-stage liver disease (HBV, PBC…) * Patients with preoperative infections, infections within 48 h after transplantation or early post-operative death

Outcomes

Primary Outcomes

Determine the types of early bacterial infections following LDLT, recurrent and resistant infections all were confirmed by cultures.

Bile, abdominal drains, blood stream infection, urinary tract infection or chest infection.

Time frame: Within the first 90 days after the operation

Assessment of risk factors for occurrence of recurrent bacterial infections

Independent risk factors for infections

Time frame: The first 3 months following LDLT

Data from ClinicalTrials.gov

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