Predictors of Pulmonary Hypertension in Patients With Advanced Lung Diseases

Silesian Centre for Heart Diseases200 enrolled

Overview

First, the aim of the study was to evaluate the usefulness of echocardiographic parameters for detecting pulmonary hypertension (PH) in patients with advanced lung disease referred for lung transplantation. Second, to assess the prevalence of PH and to identify which hemodynamic, echocardiographic, pulmonary functional test, exercise capacity and biochemical parameters (especially NT-proBNP) have an impact on survival in a cohort of patients with severe lung diseases referred for lung transplantation.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Pulmonary Hypertension

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * advanced lung disease * qualification for lung transplantation * written informed consent * pulmonary capillary wedge pressure \< 15 mmHg Exclusion Criteria: * cancer, * history of idiopathic pulmonary hypertension, * primary valvular heart diseases, * coronary artery disease, * collagen vascular disease, * history or evidence of left ventricular dysfunction, * atrial fibrillation, * increased liver enzyme levels ( 3 times the upper laboratory limit), * renal dysfunction (estimated glomerular filtration rate \< 60 ml/min/1.73m2) * patients who didn't write the personal informed consent * any specific therapy for PH.

Locations (1)

Silesian Centre for Heart Diseases

Zabrze, Silesian Voivodeship, Poland

Outcomes

Primary Outcomes

Survival after the initial right heart catheterization (RHC) measurements

Time frame: 1 year

Secondary Outcomes

Survival to lung transplantation or the end of the observation period after the initial right heart catheterization (RHC) measurement

Time frame: 3 years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.