RETRO (REduction of Therapy in RA Patients in Ongoing Remission)

Inclusion Criteria: * Must understand and voluntarily sign an informed consent form including written consentfor data protection * Must be able to adhere to the study visit schedule and other protocol requirements * Must be male or female and aged ≥ 18 years at time of consent * Must have a diagnosis of RA according to ACR criteria \[26\] for at least 12 months * Must have a DAS 28 score of less than 2.6 (means: remission) at randomization (documented in at least three subsequent controls for six months; compare figure three in the appendix for details) * At screening-visit patients should have been treated without alterations of therapy for at least six months with one of the following therapies: (i) one or more of the following conventional DMARDS (with or without concomitant use of glucocorticoids): Methotrexate, Leflunomide, Ciclosporine A, Sulfasalazine, Azathioprine or Hydroxychloroquine, (ii) a combination of a conventional DMARD (Methotrexate, Leflunomide, Ciclosporine A, Sulfasalazine, Azathioprine or Hydroxychloroquine) with one of the following biologicals (with or without concomitant use of glucocorticoids): Infliximab, Adalimumab, Etanercept, Tocilizumab, Golimumab, Certolizumab, Abatacept, (iii) or one of the biologicals mentioned above without combination with a conventional DMARD. All of the aforementioned biologicals are also allowed in combination with glucocorticoids, (iv) monotherapy treatment with glucocorticoids (without any DMARD or biological treatment). Exclusion Criteria: * Treatment with Rituximab during the last 12 months before screening * Intake of a daily dosage of more than 5mg Prednisolone - equivalent during the last 6 months before randomization; intraarticular injections of glucocorticoids do not represent an exclusion criteria * Current treatment with other DMARDS (for example MMF or preparations still in development) than mentioned above * Any anti-inflammatory or immunosuppressive therapy for other reasons than RA during the last 3 months before screening * Any condition, including the presence of laboratory abnormalities, which places the subject at unacceptable risk if he/she were to participate in the study or confounds the ability to interpret data from the study * Any other rheumatological/immunological disease such as Psoriasis, Psoriatic Arthritis, SLE, PSS, MCTD, M. Bechterew, M. Behcet or M. Wegener. Should the respective diagnosis be confirmed after inclusion into the study the patient will leave the study and data is recorded via "unscheduled visit"- and follow-up form * Florid autoimmune conditions such as autoimmune hepatitis or Hashimoto's disease while still under treatment * Patients with a florid malignancy * Participation in another phase 1-4 treatment study for RA * Patients who are younger than 18 years or are incapable to understand the aim, importance and consequences of the study and to give legal informed consent (according to § 40 Abs. 4 and § 41 Abs. 2 und Abs. 3 AMG) * Pregnant or lactating female * Females of childbearing potential (FCBP is a sexually mature female who 1. has not undergone a hysterectomy or bilateral oophorectomy, or 2. has not been postmenopausal for at least 24 consecutive months) have to use adequate forms of contraception with respect to standard treatment recommendations. However if there is suspicion of a pregnancy in spite of standard treatment recommendations a urine pregnancy test is to be carried out by the Investigator * Also males must also use adequate forms of contraception * Patients who possibly are dependent on the Principal Investigator or investigator