Reproductive Outcome of EM Treated by GnRH-a Associated With Laparoscopy

Peking University People's Hospital1,184 enrolled

Overview

This study is a multicenter, randomized-control-trial. This study select 1184 Infertile patients associated with endometriosis diagnosed by laparoscopy surgery. Patients are going to be divided into two groups according to 1:1 ratio randomly assigned to receive GnRH-a. Cumulative pregnancy rate, end of treatment to natural pregnancy time, accept the assisted reproductive treatment rate, miscarriage rate, live birth rate will be recorded.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

1,184

Conditions

Infertility Associated With Endometriosis

Interventions

Goserelin AcetateDRUG

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 35 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Infertile patients * Endometriosis I-II phase：according to Revised American Society for Reproductive Medicine classification of endometriosis: 1996 * BMI:19-28 kg/㎡ * Ovarian reserve function is normal（M2-5：bilateral antral follicles≥6 FSH：5-12U/ml） Exclusion Criteria: * Male factor causes infertility * hydrosalpinx or salpingemphraxis * Uterine malformation * Uterine cavity lesion * Contra-indications for GnRH-a * not willing to participate

Outcomes

Primary Outcomes

Cumulative pregnancy rate

Cumulative pregnancy rate of 18 month after surgery

Time frame: 18 month after surgery

Time interval between surgery and natural pregnancy

Time frame: 18 month after surgery

miscarriage rate

miscarriage rate of patients who get natural pregnancy

Time frame: 18 month after surgery

Data from ClinicalTrials.gov

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