The aim of the study is to examine the effect of RIPC on physiological parameters in non-valvular paroxysmal atrial fibrillation. Furthermore the study will provide a unique bio-date base for further analysis of molecular and genetic mechanisms responsible for observed results. The potential effect of RIPC on AF inducibility and/or prothrombotic activity might be implemented as additional treatment component to reduce AF burden and minimize thromboembolic risk. Interim Analysis will be done after 73 patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
146
RIPC will be induced by the application of 3 short episodes (5 minutes) of forearm ischemia by cuff sphygmomanometer inflation separated by 5 minutes of reperfusion.
In the control group the cuff will be inflated for 3 times at 10 mm Hg for 5 minutes with 5-minute intervals
Herzzentrum Leipzig
Leipzig, Germany
RECRUITINGinducibility of Atrial Fibrillation by high-rate pacing of 20 s
Time frame: during the Atrial Fibrillation Ablation procedure
sustainability of Atrial Fibrillation measured in seconds
Time frame: during the Atrial Fibrillation Ablation procedure
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