Influence of Gender Specific Differences of Saliva Composition on the Development of Dental Erosion - an In-situ Study

University of Göttingen50 enrolled

Overview

Healthy volunteers are observationally wearing an intraoral device with bovine tooth samples once for two hours. Afterwards, Calcium release from the bovine enamel and dentin samples is measured after extraoral erosion. Total protein concentration within the formed salivary pellicles on the bovine samples is determined. Further Salivary parameters (unstimulated and stimulated saliva flow rate, pH, buffer capacity, albumin and total protein content as well as concentration of inorganic calcium, phosphate and fluoride) are being measured. The aim of this study is to investigate whether gender differences in the salivary composition correlate with predisposition to erosion.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Dental Erosion

Interventions

Wearing of an intraoral device with bovine tooth samplesOTHER

Wearing of an intraoral device with bovine tooth samples

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy probands aged between 20 and 40 years who are able to give written consent Exclusion Criteria: * Non-fulfillment of the inclusion criteria * Smoking * Hyposalivation / xerostomia (unstimulated saliva \< 0.3 mL/min, stimulated saliva \< 0.7 mL/min) * Intake of any medication (except contraceptives in women) * Pregnant or lactating women * Known allergies to substances used in the study * Orthodontic treatment or malfunction which doesn't allow to wear an intraoral device

Outcomes

Primary Outcomes

Calcium release from bovine enamel and dentin samples by extraoral erosion (nmol/Square Millimeter).

Time frame: Immediately after the intraoral device has been worn once for two hours.