Culture of Circulating Tumor Cells Isolated From Cancer Patients With Metastatic Disease

Inclusion Criteria: * Patients with any metastatic solid tumor malignancy. Metastatic is defined as biopsy proven disease involving at least one organ other than the primary tumor organ. Regional lymph node metastases are not considered metastatic. Patients with newly diagnosed metastatic disease who have not had systemic therapy in at least six months or are progressing on systemic therapy will be eligible for enrollment. * Scheduled to initiate radiation for management of their disease, and schedule accommodates blood sample collection prior to radiation * Male and female of ≥18 years of age * Male and female patients capable of reproduction must agree to use medically acceptable methods of contraception, such as an intra-uterine device, diaphragm, with spermicide, condom with spermicide or abstinence, during radiation therapy. Inclusion of females of childbearing potential requires a negative pregnancy test within 14 days prior to study initiation (part of standard of care in radiation oncology). * Written informed consent obtained and signed * Able to have blood collection without excessive difficulty Exclusion Criteria: * Patient unwilling or unable to complete informed consent * Physical or psychological inability to complete sample collection for any reason including but not limited to: inability to tolerate any study procedures, any physical limitation that would undermine the safety of the subject in the study, or any psychiatric or neurological condition that inhibits full comprehension of study requirements and inability to complete informed consent, as determined by treating physician * Currently pregnant or lactating women