In this study, navigation of lymphatic passage after sentinel lymph node with indocyanine green was performed during axillary lymph node dissection in breast surgery . By comparing the concordance between the passage of indocyanine green and actual lymph node metastasis, selective lymph node dissection can be developed.
Low dose of indocyanine green emits near-infrared fluorescence, which can penetrate thin tissues like breast or skin. The operator can track the lymphatic pathway without skin incision in real time. By these characteristics, indocyanine green is currently used for sentinel lymph node biopsy in breast cancer surgery. Indocyanine green can also stain lymph nodes beyond the sentinel lymph nodes. This is why we can identify the lymphatic metastasis pathway of breast cancer.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
150
Lymph node dissection is performed in axillary lymph node level I and II. In case of palpable nodes in level II, additional lymph node dissection in level III is done.
10cc of 20μg/mL indocyanine green is injected at the nipple-areola complex before surgery
Near-infrared fluorescence is collected by imaging lenses and digital camera.
Samsung medical center
Seoul, South Korea
RECRUITINGNumber of metastatic lymph nodes in fluorescent positive lymph nodes and fluorescent negative lymph nodes confirmed by pathologist
Concordance analysis is done by comparing lymph node metastasis between fluorescent positive lymph nodes and fluorescent negative lymph nodes.
Time frame: within 2 weeks (plus or minus 3 days) after surgery
Clinicopathological factors associated with lymph node metastasis in fluorescent negative lymph nodes
Risk factor analysis of fluorescent negative lymph node with positive lymph node metastasis
Time frame: within 2 weeks (plus or minus 3 days) after surgery
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