Mass Spectral Fingerprinting in Lung Cancer

University of Zurich309 enrolled

Overview

To answer the question whether a disease specific profile of breath in patients with lung cancer can be detected by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.

Study Type

OBSERVATIONAL

Enrollment

309

Conditions

Lung Cancer

Interventions

No interventionOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Confirmed lung cancer based on cytological or histological analysis. * Group A: any type of lung cancer eligible for surgical resection (up to TNM stage IIIa). * Group B: any type of lung cancer (small-cell carcinoma, non-small-cell carcinoma) not amenable for surgical resection. * Group C: matched controls. * Age between 18 and 85 years at study entry Exclusion Criteria: * Another 'active' secondary malignant disease (e.g. breast cancer, colon carcinoma) in group A and B, presence of any active malignant disease in group C (based on personal information). * Acute inflammatory disease (e.g. common cold) within the last 4 weeks. * Any other acute lung disease which affects breath measurements * Acute or chronic hepatic disease. * Renal failure or renal replacement therapy.

Locations (1)

University Hospital Zurich, Division of Pneumology

Zurich, Canton of Zurich, Switzerland

Outcomes

Primary Outcomes

Concentration of volatile organic compounds (VOCs) in the exhaled breath will be analysed using mass spectrometry

The primary outcome will be the lung cancer specific mass spectrometric profile of VOCs of exhaled breath analysis (markers of lung cancer in exhaled breath).

Time frame: 1 day, single measurement

Secondary Outcomes

Group A: Concentration of volatile organic compounds (VOCs) in the exhaled breath will be analysed using mass spectrometry before and after lung cancer surgery

The acquired profiles of mass spectral VOCs before and after lung cancer surgery will be analysed for significant differences.

Time frame: Group A: 2 measurements on 2 different days; Day 1: 1. measurement (before surgery), Day 2: (6-12 weeks after surgery): 2. measurement

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.