The study is prospective, double blinded, randomised controlled and has the purpose to compare the analgesic effects of ketorolac or morphine intravenous in low back pain.
The study will take place in the Emergency Department of the Clinical Emergency Hospital Bucharest and will compare the analgesic effects of ketorolac tromethamine against morphine in low back pain. The patients will be randomised to receive either ketorolac 30 mg intravenous (diluted in 20 ml of 0,9% saline) or morphine 0,1 mg/kg weight intravenous. A scale of 1-10 will be used for measuring the pain, and the effects of the treatment will be evaluated at 15 minutes and 30 minutes from the administration of the drugs. After 30 minutes if there is no significant reduction of the pain a rescue therapy will be used : acetaminophen 1 g, sodic metamizole 1g both diluted in 500 ml saline and the other medication not used from the study (morphine or ketorolac tromethamine).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
100
Reducing the grade of pain
To see the reducing of the pain on a scale 1-10 at two time points
Time frame: 15 minutes, 30 minutes
Time of staying in emergency department
Time frame: 30 minutes, 1 hour, 2 hours, 3 hours
The necessity neurosurgery consult - questionnaire
The patients will be called after 1 month to see if they needed an appointment with the neurosurgeon.
Time frame: 1 month
The cost of each treatment
Time frame: 1 hour
The necessity to use rescue therapy
30 minutes from presentation in the ED - if the pain is still \> 5 on a 1-10 scale
Time frame: 30 minutes
Side effects of each treatment
Time frame: 30 minutes
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