Efficacy of Microfragmented Lipoaspirate Tissue in Arthroscopic Rotator Cuff Repair

Inclusion Criteria: * 18\< Age \< 75 years. * a full-thickness tear of the supraspinatus and/or infraspinatus tendons (classified according to Snyder as degree C1, C2, C3). * Indication for arthroscopic rotator cuff repair. * Patients able to understand the study conditions and willing to participate for its entire duration. * Patients who signed written informed consent. Exclusion Criteria: * Patients diagnosed with partial supraspinatus/infraspinatus tears (A1, A2, A3, A4, B1, B2, B3, B4 in Snyder classification system). * Patients diagnosed with massive rotator cuff tears C4 in Snyder classification system). * Patients diagnosed with subscapularis tears, of grade III, IV or V in Lafosse classification. * Patients diagnosed with anterior, posterior or multidirectional shoulder instability. * Patients diagnosed with Superior Labrum Anterior-to-Posterior (SLAP)-type long-head of the biceps tendon lesions. * Patients presenting serious comorbidities, which represent contraindications to shoulder arthroscopy. * Patients treated with hyaluronic acid or steroid intra-articular injections in the index shoulder less than 3 months before the procedure. * Patients diagnosed with local (shoulder, site of fat tissue harvest or nearby tissues) or systemic infections, osteomyelitis, sepsis. * Fatty degeneration/atrophy grade III or IV (Goutallier or Fuchs classification) in supraspinatus or infraspinatus muscle bellies. * Patients diagnosed with diabetes * Patients diagnosed with chronic kidney disease with Glomerular Filtration Rate (GFR) less than 60 mL/min. * Patients diagnosed with any disease of coagulation or platelet aggregation systems, or treated with oral anti-coagulating or anti-aggregating agents for which no suspension is possible at the moment of intervention. * Patients chronically treated with immune-suppressants agents. * Patients affected by chronic heart failure. * Patients diagnosed with acute coronary or cerebrovascular disease in the last 6 months. * Patients who reported weight loss greater than 30 kg for any reasons in the last 12 months or, if the cause is unknown, greater than 10 kg in the last 12 months if the cause * Patients diagnosed with eating disorders or body dysmorphic disorders. * Patients with untreated hypo- or hyperthyroidism. * Patients with varicose veins, phlebitis or scars near the fat tissue harvest area. * Drug-addicted, alcohol-addicted patients, patients with psychiatric disorders or other clinical conditions, which could compromise the results of the surgical procedure or of the follow-up. * Informed consent not accepted. * Pregnant or breastfeeding women.