The purpose of this study is to evaluate the effects of different dexmedetomidine on the propofol requirement for loss of consciousness undergoing bispectral index.
It has been shown that dexmedetomidine was an efficacious and safe adjuvant in general anaesthesia. Administration of dexmedetomidine during the preoperative period has been demonstrated to reduce the requirement of opioid analgesics and other sedative and hypnotic drugs.Therefore, the study is designed to measure the effect of intravenous dexmedetomidine premedication on the propofol dose requirement and bispectral index at loss of consciousness.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
73
receive equal volume of normal saline
receive dexmedetomidine 0.5 µg/kg
receive dexmedetomidine 1.0 µg/kg
The propofol requirement for pretreatment of dexmedetomidine by micro-pump until loss of consciousness
Time frame: To infuse dexmedetomidine and saline completely ten minutes after
The bispectral index values when patients loss of consciousness
Time frame: To infuse dexmedetomidine and saline completely ten minutes after
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