Effects on Cardiovascular Risk Factors of the Endogenous Hydroxytyrosol Generation After the Combined Intake of Wine and Tyrosol in Humans

Inclusion Criteria: 1. Understanding and accepting the study procedures and signing the informed consent. 2. Male and female volunteers aged 50 to 80 years. 3. Participants with at least three major cardiovascular risk factors, including: * current smoking (\>1 cig/day during the last month) * hypertension ≥140/90 mmHg or antihypertensive medication * low-density lipoprotein (LDL)-cholesterol \>130 mg/dl or lipid-lowering therapy * low high-density lipoprotein (HDL)-cholesterol ≤40 mg/dl in men or ≤50 mg/dl in women * overweight/obesity (body mass index≥25 kg/m2) * a family history of premature coronary heart disease (CHD). 4. Clinical diagnosis of type 2 diabetes. 5. Clinical history and physical examination demonstrating no organic or psychiatric disorders. 6. The ECG and general blood and urine laboratory tests performed before the study should be within normal ranges. Minor or occasional changes from normal ranges are accepted if, in the investigator's opinion, considering the current state of the art, they are not clinically significant, are not life-threatening for the subjects and do not interfere with the product assessment. These changes and their non-relevance will be justified in writing specifically. 7. Subjects socially drinking and who had ingested wine at least once. 8. Acceptance of following a controlled diet with a moderate content of antioxidants along the study, in which time it will be not permitted the consumption of wine/champagne (except in the framework of treatment conditions in the clinical trial) or other alcoholic drinks (beer, spirits…), but it will be allowed a maximum of: (i) Vegetables (including pulses): one serving (small dish)/day; (ii) Fruits (or juices): 2 pieces/day; (iii) Commercial olive oil: maximum 25 mL/day; (iv) Drinks containing xanthines (coffee, tea, cola, energy drinks…): maximum 3 cups/day; (v) Chocolate: maximum one piece (small, 15 gr)/day; (vi) Nuts: maximum 30 g (a small handful)/week; and (vii) Fish: maximum 3 times per week (150g/serving). Exclusion Criteria: 1. Not meeting the inclusion criteria. 2. Participants with BMI \>40kg/m2 3. Participants who intake antioxidant supplements. 4. Participants with multiple allergies or intestinal diseases. 5. Participants who follow special diets (vegetarian and vegan diets included). 6. Participants with any condition limiting their mobility, making study visits impossible or worsening the adherence to the treatments. 7. Participants with history of hypersensitivity or intolerance to ethanol. 8. Ethanol users of \>80 g/d (v) and illicit drug users. 9. Illiteracy. 10. Participants with an acute infection or inflammatory process in the last three months (may be included if the episode developed prior to 3 months). 11. Participants with history of previous cardiovascular disease (coronary heart disease or stroke) 12. Participants taking medication with sedative effects or interacting with ethanol. 13. Participation in other clinical trials with drugs in the previous 12 weeks