The investigators will investigate the effects of an 8-week resistant starch (RS) supplementation (5 g twice a day) in patients with Parkinson Disease and matched controls on: 1. symptoms of constipation (assessed by clinical scores); 2. fecal short chain fatty acid concentrations (measured by chromatography); 3. gut microbiota composition.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
95
Subjects in this arm will receive General recommendations with regard to nutrition based on the guidlines of the German Society for nutrition
Saarland University
Homburg / Saar, Saarland, Germany
Bowel habits
Number of patients with improved bowel habits
Time frame: 8 weeks
Fecal short chain fatty acid (SCFA) concentrations
Number of patients with either a) increased, b.) unaltered or c) decreased concentration of short chain fatty acids in fecal samples at 8 weeks (compared to baseline)
Time frame: 8 weeks
Analysis of fecal microbiota composition
Analysis to detect changes between baseline and 8 weeks of resistant starch supplementation
Time frame: 8 weeks
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