Gonadotropin Releasing Hormone Antagonist in Treatment of Early-onset Severe Ovarian Hyperstimulation Syndrome

Ain Shams University84 enrolled

Overview

Efficacy of the use of GnRH antagonist in treatment of those who develop early-onset severe ovarian hyperstimulation syndrome and had cancelled embryo transfer

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Assisted Reproduction

Interventions

CetrorelixDRUG

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 42 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women who develop early-onset severe ovarian hyperstimulation syndrome after controlled ovarian stimulation using long GnRH agonist protocol and hCG for triggering ovulation. Exclusion Criteria: * Women on short or antagonist protocols. * Women who received GnRH agonist for triggering ovulation. * Women who had embryo transfer.

Outcomes

Primary Outcomes

Number of women who needed culdocentesis or paracentesis of the ascitic fluid

Time frame: within 2 weeks of onset

Secondary Outcomes

Number of women who needed hospitalization

Time frame: within 2 weeks of onset of symptoms

Time to regression of nausea/vomiting

Time frame: within 2 weeks of onset of symptoms

Time to regression of large ovarian size

Time frame: within 4 weeks of onset of symptoms

Data from ClinicalTrials.gov

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