This study assesses the benefits of continuous intravenous lidocaine administration during sedation for colonoscopy. Sedation will consist of propofol infusion titrated to provide adequate working conditions to the gastroenterologist. Patients will be randomly allocated into two groups: lidocaine infusion (bolus of 1.5 mg/kg followed by a continuous infusion of 4 mg/kg/h) or the same volume of placebo (normal saline)
The potential benefits of lidocaine infusion will be tested on: * propofol consumption (primary outcome) * intraoperative respiratory depression * time for patient recovery * postoperative fatigue * postoperative pain * postoperative cognitive dysfunction
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
40
Propofol (0.5 mg/kg or more) is titrated to provide loss of consciousness. Then in the lidocaine group, lidocaine 2% is administered as a bolus followed by a continuous intravenous infusion after loss of consciousness
Propofol (0.5 mg/kg or more) is titrated to provide loss of consciousness. Then in the placebo group, the same volume of normal saline is administered after loss of consciousness
University Hospital of Liege
Liège, Belgium
Consumption of propofol
Dose of propofol administered during sedation if measured at the end of it.
Time frame: intraoperative
Episodes of oxygen desaturation
Episodes of oxygen desaturation: SpO2 \< 95 and 90%
Time frame: intraoperative
Time for recovery
the patient is discharged when conscious and able to give his birth date
Time frame: intraoperative
Quality of working conditions assessed by the gastroenterologist
Time frame: intraoperative
Abdominal discomfort
Evaluation with VAS (visual analog scale) form 0 (no discomfort) to 10 (unbearable Abdominal discomfort assessed on a 0 to 10 visual analog scale
Time frame: intraoperative and 15 minutes later
Postoperative fatigue
Fatigue will be assessed on a visual analog scale
Time frame: 15 min after sedation
Cognitive condition
Cognitive condition will be evaluated with the MMSE (Minimal Mental State Examination)
Time frame: 15 minutes after sedation
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