Adjuvant Chemotherapy Combined With Huaier Granule for Treating High-risk Stage II, Stage III Colorectal Cancer

Inclusion Criteria: * The subjects volunteer to sign the informed consent * Aged: 18 to 75 years old * Colorectal cancer (AJCC-TNM, high-risk Stage II and Stage III) * The diagnosis and colorectal cancer has been confirmed by pathological examination after radical surgery * The liver and kidney function satisfies the following conditions within 15 days after surgery (excluding day 15): aspartate aminotransferase (AST), glutamic-oxalacetic transaminase (ALT), alkaline phosphatase (ALP)\< 2 upper limit of normal (ULN), total bilirubin ≤ 1.5 ULN, serum creatinine \< 1.5 ULN; normal coagulation function * Other laboratory tests meet the following requirements within 15 days after surgery (excluding day 15): white blood cells count ≥ 3.0×109/L, absolute neutrophil count ≥ 1.5×109/L, platelet count ≥ 100×109/L * ECOG：0-2 points * No other previous history of malignancy. Exclusion Criteria: * Multiple primary cancer * Not recover from the colorectal surgery * Presence of organ, bone, or skin metastases * Pregnant or lactating women * Those with active bleeding due to various reasons * Those with HIV infection or AIDS-associated diseases * Those with severe acute and chronic diseases * Those with severe diabetes * Those with serious infectious diseases * Those who can not take drugs by oral route * Drug abusers or those with psychological or mental diseases that may interfere with study compliance * Conditions that are considered not suitable for this study investigators